In the fight against zika—the mosquito-spread virus recently declared an international public health emergency due to its potential link with a brain deformity in infants—there are those who argue we should wipe out the insect entirely. But there are many questionsabout what the ecological impacts of destroying an entire population—or even an entire species—of mosquitoes might be. What if instead of modifying the mosquitoes to wipe out the insects, we modified them to wipe out the virus?

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