Universal made it a date movie, drew more women than men, scored a $51 million opening and may have launched a sequel Loud and lewd, the raucous comedy “Neighbors” hardly seemed a natural for Mother’s Day weekend. But it turned out to be an ideal date for the raunchy R-rated romp starring Zac Efron, Seth Rogen and Rose Byrne, which the pulled off summer’s first stunner with an opening estimated at $51 million that brought down reigning champ “The Amazing Spider-Man 2.” Universal Pictures wasn’t talking Monday, but when you take in that kind of money — and another $34 million from overseas — with a movie that cost $18 million, it’s safe to say the team there is thinking sequel. The opening for “Neighbors” — about a young family whose life is turned upside down when a fraternity moves in next door — was about $10 million higher than most analysts had projected. A big reason for that was the gender breakdown: women made up the majority of the audience at 53 percent. That’s for a movie rife with a frequently nude Rogen, obscene topiaries, breast-feeding gags, dildo fights and beyond.

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