Nanoparticles which help deliver curcumin, a natural compound with potential to cure Alzheimer’s, to rat brain have been created RESEARCH by an Indian team could provide an important breakthrough in finding cure to Alzheimer’s disease. The team has successfully ferried curcumin, a natural compound found in turmeric, to rat brain by trapping it inside polymer nanoparticles.

Curcumin has shown promise as a potential cure for neurodegenerative ailments such as Alzheimer’s, but delivering curcumin to the brain has been a challenge. Studies have shown that only 15 per cent of curcumin consumed reaches the brain. A major part of it fails to cross the blood-brain barrier or the protective shield around the central nervous system.

To overcome this, the researchers synthesised curcumin-loaded nanoparticles using a drug-releasing polymer, poly (lactic-co-glycolic) acid. They then studied the ability of these nanoparticles to release curcumin in rat brain. They also tested its biocompatibility and accumulation.

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