suppresses the adaptive immune response in the host could lead to development of new drugs to control the disease. The team of scientists led by Dr. Sangita Mukhopadhyay, Group Leader, and Laboratory of Molecular Cell Biology at the Centre for DNA Fingerprinting and Diagnostics (CDFD) has found that Mycobacterium tuberculosis protein ESAT-6 suppresses host?? protective functions. They identified that ESAT-6 directly binds with host molecule beta-2 microglobulin and inhibits antigen presentation to CD8 T-cells which play a key role in protective immune response mechanism of the host. Dr. Sangita said the CD8 T-cells recognise the infected immune cells and directly kill them. The ESAT-6 protein through its
interaction with the host molecule would delay or inhibit the CD8 T-cells immune response, which was important to control the disease.

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