In all of human history, we’ve only ever been able to completely wipe out one disease: smallpox. Declared eradicated by the World Health Organization in 1980, smallpox was cleared from the face of the Earth following an aggressive global immunization campaign. The annual letter by Bill and Melinda Gates was recently published, and it includes some predictions for the future primarily in the way of public health. The letter ambitiously hopes and predicts that the world will have eradicated four diseases from the Earth in the next 15 years, thanks in part to vaccines and drugs becoming more readily accessible with time. The letter isn’t specific on which four diseases those will be, although it strongly predicts polio and Guinea worm as being two of the four. Other possible candidates for the remaining two include elephantiasis, river blindness and blinding trachoma.

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